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德诺苏马布用于治疗缺骨骨中的不可手术的巨细胞瘤

Aaron Gerarde Paul¹, Lei Peng See¹, May Honey Ohn²

¹Orthopaedic Surgery, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia.

BMJ case reports

|December 18, 2023

概括

骨巨细胞瘤是一种罕见的良性瘤,可以发生在平坦的骨中. 德诺苏马布疗法有效地治疗了一种巨大的石骨巨细胞瘤,使其可用于手术切除和重建.

科学领域:

整形瘤学整形瘤学
骨的瘤骨的瘤
医学瘤学医学瘤学

背景情况:

巨细胞骨瘤 (GCTB) 是一种良性,局部具有攻击性的骨解性瘤.
GCTB通常影响骨成熟的年轻人,主要发生在长骨的甲中.
发生在平坦的骨头,如椎骨,是非常罕见的.

研究的目的:

为了呈现一种罕见的巨细胞骨瘤的案例.
要突出成功使用登索马布治疗在管理一个大,潜在的不可操作的GCTB.
描述经过新辅助性denosumab治疗后的手术方法和重建.

主要方法:

一位20多岁末的女性呈现出一块大的右侧腰椎质量.
活检证实了这种质量是巨细胞瘤,延伸到囊.
在手术切除 (2型和3型内部半皮切除术) 和关节内置假体重建之前,进行了新辅助代诺苏马布治疗.

主要成果:

德诺苏马布治疗成功地降低了瘤的发展阶段,使得以前无法手术的病变易于进行外科手术.
患者经历了成功的内部半皮切除术和关节内置假体的重建.
在手术期间没有报告与出血或污染相关的直接并发症.

结论:

石骨巨细胞瘤是一种罕见的表现,需要量身定制的管理.
德诺苏马布治疗是一种有价值的新辅助治疗选择,用于大或不可切除的GCTB,以促进外科切除.
带有内置假肢重建的彻底手术可以在广泛的骨盆GCTB中获得有利的结果.

关键词:

与手术相关的药物治疗与手术有关.整形外科和创伤外科手术手术瘤学手术瘤学

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