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精神分裂症和双极性谱系障碍的内部和个人间的认知变化:跨多个认知领域的调查
Beathe Haatveit1,2, Lars T Westlye3,4,5, Anja Vaskinn6,7
1Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. beathe.haatveit@medisin.uio.no.
Schizophrenia (Heidelberg, Germany)
|December 18, 2023
概括
精神分裂症和双相情感障碍患者表现出比健康个体更大的认知可变性. 认知功能的这种变化与这些患者群体的症状严重程度和功能有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 呈现出显著的认知异质性.
- 了解认知表现的变化对于理解这些疾病中的认知障碍至关重要.
研究的目的:
- 调查SZ,BD和健康对照 (HC) 之间的认知平均值和可变性差异.
- 探索SZ和BD患者认知变异的临床相关性.
主要方法:
- 采用双通用线性模型 (DGLMs) 来分析22个认知变量.
- 在SZ (n=905),BD (n=522) 和HC (n=1170) 组中比较认知表现和可变性.
主要成果:
- 在90%的认知变量中观察到显著的病例控制差异.
- 与HC相比,SZ和BD患者在处理速度,运动速度和抑制控制方面表现出更大的个体内和个体间变异性.
- 在SZ中,变异性与负面症状和功能低下相关;在BD中,它与功能,症状,疾病持续时间和药物使用有关.
结论:
- 与健康个体相比,SZ和BD患者在多个领域中表现出较高的认知可变性.
- 认知变异性与SZ和BD的临床特征和功能结果有关.
- 进一步研究认知变化的起源和影响是必不可少的.
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