后COVID-19患者的生物标志物景观可以建议选择性临床干预
Debora Paris1, Letizia Palomba2, Maria Cristina Albertini2
1Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli (Naples), Italy.
Scientific reports
|December 18, 2023
概括
呼出气凝液 (EBC) 中的生物标志物揭示了COVID-19后综合征患者的不同代谢概况. 这些发现突显了持续的炎症和器官系统失调,指导了有针对性的康复策略.
科学领域:
- 生物化学 生物化学
- 基因组学就是基因组学.
- 肺部病理学 肺部病理学
背景情况:
- COVID-19可以导致持续的症状,称为后COVID-19条件,即使在轻度或中度疾病后.
- 了解COVID-19后的潜在生物机制对于开发有效治疗方法至关重要.
研究的目的:
- 在呼出的呼吸凝凝液 (EBC) 中识别生物标志物,以表征COVID-19后的临床状态.
- 为了将这些生物标志物与后COVID-19患者的临床参数相关联.
主要方法:
- 基于核磁共振 (NMR) 的代谢学被用于分析38名COVID-19后患者和38名健康对照的EBC.
- 预测COVID-19可以调节的微RNAs (miRNAs) 在EBC中得到量化.
- 来自COVID-19后患者的临床数据与代谢发现相关.
主要成果:
- 在COVID-19后的患者和对照人群中观察到不同的代谢表型 ("代谢型").
- 在COVID-19后的患者中,丰富分析确定了特定的miRNA (hsa-miR146a-5p上调;hsa-miR-126-3p和hsa-miR-223-3p下调).
- 代谢数据与临床参数相关,表明持续的炎症,肝脏和血管调节失调以及身体损伤.
结论:
- 多omics数据揭示了与COVID-19后状态相关的关键生物标志物.
- 这些生物标志物表明持续的炎症,肝脏失调,内血管血栓和肺部过程.
- 针对这些过程对于在康复之前管理COVID-19的急性后续症状至关重要.
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