支持有利的生理适应的分子机制,以进行泌尿癌手术的预康复
James E M Blackwell1,2, Nima Gharahdaghi1, Colleen S Deane3
1MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby, UK.
高强度间歇训练 (HIIT) 预康复改善了泌尿癌患者的心肺呼吸能力,通过增强骨肌肉线粒体功能. 这项研究没有发现HIIT增加肌肉蛋白质合成的证据.
科学领域:
- 运动生理学 运动生理学
- 在瘤学瘤学.
- 线粒体生物学 线粒体生物学
背景情况:
- 泌尿癌手术导致不良结果,包括疲劳和降低生活质量.
- 使用高强度间歇训练 (HIIT) 进行手术预康复可以改善泌尿癌患者的心肺呼吸能力 (CRF).
- 在这个患者群体中,HIIT的好处背后的确切机制尚不清楚.
研究的目的:
- 调查HIIT作为泌尿癌患者手术预康复的积极影响背后的生理机制.
- 评估HIIT对线粒体氧化酸化 (OXPHOS) 能力,肌肉蛋白合成 (MPS) 和相关信号通路的影响.
主要方法:
- 19名接受重大泌尿外科手术的男性患者被随机分配到4周的HIIT预康复组或对照组.
- 在干预之前和之后,采取了m. vastus lateralis的肌肉活检.
- 分析的重点是线粒体OXPHOS容量,MPS,以及合成代谢,代谢和胰岛素信号传递.
主要成果:
- HIIT预康复显著增加了骨肌肉线粒体OXPHOS容量,由电子运输链复合体的增强表达证明.
- 在特定电子运输链复合体的改进和CRF的增长之间观察到强烈的相关性.
- 高强度炼并没有显著增加累积肌纤维肌肉蛋白合成 (MPS) 或改变合成/代谢蛋白表达,但它确实增加了AS160.0的酸化.
结论:
- HIIT预康复增强骨肌肉线粒体OXPHOS容量,提供了改善泌尿癌患者CRF的潜在机制.
- 观察到的MPS刺激缺乏表明HIIT预康复,在这个协议中,不会促进肌肉缩.
- 需要进一步的大规模试验,以将临床结果与机械学数据相关联,以优化泌尿癌患者的HIIT预康复策略.
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