斯约格伦综合征的流行病学
Maxime Beydon1, Sara McCoy2, Yann Nguyen1,3
1Department of Rheumatology, Bicêtre AP-HP Hôpital, Université Paris-Saclay, Paris, France.
Nature reviews. Rheumatology
|December 19, 2023
概括
斯约格伦综合征是一种自身免疫性疾病,呈现出多种表型,并且可以与其他连接组织疾病一起发生. 地理来源影响疾病活动,淋巴瘤是主要的死亡风险因素.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 斯约格伦综合征是一种复杂的自身免疫性疾病,具有多种不同的临床表现.
- 它可以表现为原发性Sjögren综合征或继发性其他结缔组织疾病 (CTD),如类风湿性关节炎,SLE和SSc.
- 由于诊断标准和研究设计各不相同,准确的流行率和发病率数据具有挑战性.
研究的目的:
- 探索肖格伦综合征的表型变异性.
- 调查地理原产地对疾病活动的影响.
- 评估Sjögren综合征中的死亡风险因素,特别是淋巴瘤.
主要方法:
- 对现有的关于Sjögren综合征患病率,发病率和表型的文献的综述.
- 分析影响疾病活动的因素,包括地理来源.
- 检查与腺外表现和CTD相关的死亡风险.
主要成果:
- 疾病的表型和系统活动受到地理原产地的影响.
- 腺外表现,特别是淋巴瘤,是死亡的重要风险因素.
- 与单独的CTD相比,与Sjögren综合征相关的CTD中的淋巴瘤风险似乎较高.
- 患有SLE或SSc和Sjögren综合征的患者可能比单独患有SLE或SSc的患者表现出较低的疾病活性.
结论:
- 地理因素在Sjögren综合征的系统性活动中起作用.
- 淋巴瘤代表了Sjögren综合征的临界死亡风险,特别是当与CTDs同时发生时.
- 需要进行进一步的研究,以澄清原发性Sjögren综合征的死亡率和相关CTD对疾病活动的具体影响.
更多相关视频
07:25Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
2.3K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
460
相关概念视频
01:29Autoimmune Disorders
447
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
447
01:20COPD: Pathogenesis and Clinical Features
288
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
288
01:18Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
01:11Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
01:17Gastritis-II: Pathophysiology
344
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
344
01:29Psychological and Sociocultural Causes of Schizophrenia
91
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
91