适当的外科手术前运动对外科神经认知障碍的影响:叙述性审查
Hao Feng1, Zheng Zhang1, Wenyuan Lyu1
1Department of Anesthesiology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, People's Republic of China.
Molecular neurobiology
|December 19, 2023
概括
手术期间的神经认知障碍 (PND) 在手术后很常见. 手术前的运动可以通过减少神经炎症和改善肠道健康来预防PND,提供新的治疗策略.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 手术并发症 手术并发症
背景情况:
- 术后神经认知障碍 (PND) 是老年人手术后最常见的神经并发症.
- PND与术后残疾和死亡率的增加有关.
- 目前,没有针对PNDs的特定治疗方法.
研究的目的:
- 审查PND的运动干预措施的临床和临床前证据.
- 探索PND中运动介导的神经保护的分子机制.
- 为PND预防和治疗提出新的策略.
主要方法:
- 审查当前的临床和临床前研究.
- 对参与运动神经保护作用的分子通路的分析.
- 综合有关炼和PND的证据.
主要成果:
- 运动可以改善PND的认知功能障碍.
- 关键机制包括减少神经炎症,调节肠道微生物群,改善线粒体/突触功能.
- 通过手术前的运动来维持骨肌肉质量对于预防PND至关重要.
结论:
- 术后运动在预防和治疗PND方面表现有前途.
- 对运动介导的神经保护的进一步研究提供了新的治疗途径.
- 优化骨肌肉质量和准分子通路是关键策略.
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