在辅助生殖技术中支持质阶段
Akanksha Garg1,2, Agata P Zielinska1,2, Arthur C Yeung1,2
1Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Nature reviews. Endocrinology
|December 19, 2023
概括
在体外受精 (IVF) 过程中,质阶段的支持至关重要,但人们对其了解甚少. 本综述澄清了孕激素的使用情况.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 胚胎学 胚胎学
背景情况:
- 不孕症影响6对夫妇中的1对,而试管婴儿是常见的治疗方法.
- 试管婴儿 (IVF) 卵巢刺激会扰乱自然的体阶段,损害植入和怀孕.
- 目前的黄质阶段支持协议缺乏明确的最佳参数.
研究的目的:
- 审查现有的关于试管婴儿中质阶段支持的证据.
- 确定不确定性和未来的研究方向,以优化孕激素补充剂.
- 为基于证据的黄阶段支持方案提供信息.
主要方法:
- 对生理质期和IVF诱导的改变的文献综述.
- 对荷尔蒙触发因素对质期支持需求的影响的评估.
- 对子宫内膜受体性标志物和孕激素药理动学的分析.
主要成果:
- 在试管婴儿中,超生理性卵巢刺激会导致功能障碍的白期.
- 卵细胞成熟的荷尔蒙触发因素会影响所需的质阶段支持.
- 了解子宫内膜转变和孕激素的作用是优化支持的关键.
结论:
- 在试管婴儿中,用孕激素支持乳腺期是必不可少的,但需要进一步优化.
- 澄清孕激素的最佳时间,剂量,途径和持续时间至关重要.
- 未来的研究应该专注于个性化质期支持策略.
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