老中国人的骨折风险预测 - - 叙事性审查
Yi Su1, Bei Zhou1, Timothy Kwok2,3
1Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, China.
Archives of osteoporosis
|December 19, 2023
概括
骨质疏松性骨折 (OF) 在中国构成越来越大的威胁. 本综述研究了老年中国人OF风险的预测因素和工具,强调了需要更有针对性的解决方案.
科学领域:
- 老年学是指老年学的学科.
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 骨质疏松性骨折 (OF) 在全球范围内构成重大且日益增加的健康负担,预计未来中国将面临最大的份额.
- 骨折风险因种族和地理位置而异,需要针对中国人群的特定区域证据.
- 了解OF预测因素对于在中国人口老龄化中制定有效的预防策略至关重要.
研究的目的:
- 审查中国骨质疏松性骨折 (OF) 的流行病学.
- 探索中国老年人群中OF风险的现有预测因素和预测工具.
- 确定中国OF风险评估的挑战和未来方向.
主要方法:
- 对中国骨质疏松性骨折 (OF) 的流行病学数据的系统审查.
- 骨矿物质密度 (BMD) 评估工具的评估,包括双能X射线吸收度 (DXA) 和定量超声波 (QUS).
- 分析诸如FRAX和OSTA等骨折风险评估工具及其在中国环境中的适用性.
主要成果:
- 骨折发病率在中国内部呈现区域差异,尽管香港和台湾的发病率有所下降,但中国大陆的发病率趋势呈上升趋势.
- 通过DXA测量的骨矿物质密度 (BMD) 仍然是一个有价值的预测指标,即使在中国大陆应用有限;部QUS是一个可行的替代方案.
- FRAX,特别是 BMD,对 OFs 进行了良好的歧视,临床因素可以提高其在中国老年人中的预测价值.
结论:
- 像FRAX这样的现有工具对中国老年人骨质疏松性骨折 (OF) 风险的评估充满希望,但需要验证和改进.
- 非DXA方法和临床因素提供了补充价值,特别是在资源有限的环境中.
- 需要进一步的研究来开发和验证更适用的和有针对性的骨质疏松性骨折 (OF) 风险预测指标和工具,在中国老龄人口中.
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