表皮拼接调节蛋白1在癌症进展中的作用
1Vessel-Organ Interaction Research Center (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea. mjkwon94@knu.ac.kr.
Cancer cell international
|December 19, 2023
概括
异常的拼接因素导致癌症. 表皮拼接调节蛋白1 (ESRP1) 在癌症进展中具有双重作用,影响瘤生长和药物反应,使其成为潜在的治疗点.
科学领域:
- 分子生物学分子生物学
- 癌症生物学 癌症生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由拼接因子失调或突变驱动的异常替代拼接与癌症发病和进展有关.
- 拼接因子正在成为癌症治疗的关键治疗点.
- 表皮拼接调节蛋白1 (ESRP1) 是一种表皮细胞特异的拼接因子,参与了像CD44和FGFR2.2这样的关键基因的替代拼接.
研究的目的:
- 审查目前对ESRP1在癌症进展中的作用和机制的理解.
- 讨论ESRP1在癌症中的新兴新型作用,包括它对瘤代谢和瘤微环境的影响.
- 探索针对结合因子,特别是ESRP1,用于癌症治疗的最新治疗策略.
主要方法:
- 对研究ESRP1在各种癌症类型中的功能进行的文献综述.
- 对ESRP1与表皮细胞-介质酶过渡 (EMT) 的关联及其下游目标的研究分析.
- 检查研究ESRP1对瘤细胞代谢,免疫细胞透和药物反应的影响.
主要成果:
- ESRP1在癌症进展中表现出双重作用,在某些情况下作为瘤抑制剂,在其他情况下作为促进剂 (例如,乳腺和卵巢癌).
- 低调ESRP1与EMT有关,而其表达水平与患者的预后和抗癌药物的反应相关.
- 新出现的证据表明ESRP1通过调节瘤细胞代谢和瘤微环境中的免疫细胞透来影响瘤生长.
结论:
- ESRP1在癌症中扮演着复杂且取决于背景的角色,超出了它在EMT中已知的功能.
- 准ESRP1和其他拼接因子为新型癌症治疗策略提供了一个有希望的途径.
- 进一步研究ESRP1在癌症生物学中的多方面的作用及其与瘤微环境的相互作用是有必要的.
相关概念视频
RNA Splicing
56.4K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.4K
Alternative RNA Splicing
21.2K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.2K
Chromatin Structure Regulates pre-mRNA Processing
7.0K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.0K
Epigenetic Regulation
31.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.1K
Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


