在乌干达坎帕拉的艾滋病毒感染者之间进行密集的坚持咨询后,未被抑制的病毒载荷的风险因素:一个嵌套的病例控制研究
Jonathan Izudi1,2, Barbara Castelnuovo3, Rachel King4
1Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. jonahzd@gmail.com.
AIDS research and therapy
|December 19, 2023
概括
强化坚持咨询 (IAC) 在乌干达的艾滋病毒感染者 (PLHIV) 中没有改善病毒载荷 (VL) 抑制,即使有更多的会议. 进一步的研究应该检查坚持咨询忠诚度和药物耐药性.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 艾滋病毒/艾滋病研究研究
背景情况:
- 强化坚持辅导 (IAC) 是标准的护理的人生活与人类免疫缺陷病毒 (PLHIV) 与未抑制的病毒载荷 (VL) 在抗逆转录病毒疗法 (ART).
- 在资源有限的环境中,IAC会话数量与VL抑制之间的关联仍在调查中.
研究的目的:
- 调查IAC会议的数量是否与乌干达坎帕拉艾滋病毒感染者 (PLHIV) 病毒载荷 (VL) 抑制相关.
- 为了确定与未被抑制的VL相关的因素,尽管有多次IAC会话.
主要方法:
- 进行了一个嵌套的病例控制研究,PLHIV在至少三次IAC会议后经历了未抑制的VL (病例) 和那些被抑制的VL (对照).
- 未被抑制的VL被定义为≥1000副本/毫升. 多变量后勤回归确定了病例和对照之间的差异.
主要成果:
- 在16例病例和32例对照中,人口和临床特征相似.
- 在增加IAC会话数量和未被抑制的VL之间发现了显著的关联 (调整几率比:5.09;95%CI:1.35-19.10;p=0.016).
结论:
- 增加IAC会议的频率并没有导致PLHIV这一队列中的病毒载量抑制.
- 未来的研究应该评估遵守标准化的IAC协议,并考虑对PLHIV进行药物耐药性测试,以持续的未被抑制的VL.
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