正态血压变化不会影响经过密集血压控制后的认知结果
Chao Jiang1,2, Manlin Zhao1,2, Mingxiao Li1,2
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Chaoyang, Beijing, China.
Journal of internal medicine
|December 19, 2023
概括
密集的血压控制对于高血压患者的认知健康是安全的,具有显著的姿势血压变化. 这种方法并没有恶化认知结果,即使有大量的BP转移.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 高血压患者的正静血压 (BP) 变化会影响认知功能.
- 密集的血压控制对这种特定人群的认知效应仍然不清楚.
研究的目的:
- 调查静态血压变化是否会改变强化血压干预对认知结果的影响.
- 评估高血压管理与认知障碍在具有显著姿势高血压波动的个体之间的关系.
主要方法:
- 分析了来自系统血压干预试验 (SPRINT) 的8547名参与者.
- 使用考克斯模型和受限制的立方脊线曲线,评估静态BP变化和事件认知结果之间的关联.
- 评估静态血压变化与强化血压干预之间的相互作用.
主要成果:
- 在基线静态静态静态血压BP变化和认知结果之间观察到U形关联.
- 在静态血压变化 (静态或静态) 与痴呆症或轻度认知障碍 (MCI) 的强化血压干预之间没有发现显著的相互作用.
- 强化血压治疗有利于在不同程度的正静性静脉血压变化中获得认知结果,包括显著的减轻或增加.
结论:
- 强化血压控制不会对高血压患者的认知结果产生负面影响,而高血压患者的姿势血压变化显著.
- 这些发现表明,密集的血压管理是这种患者群体认知健康保护的可行策略.
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