艾滋病毒和2型糖尿病:一个不断发展的故事
Harriet Daultrey1, Tom Levett1, Nick Oliver2
1Brighton and Sussex Medical School, Brighton, UK.
HIV medicine
|December 19, 2023
概括
艾滋病毒感染者 (PLWH) 面临2型糖尿病的更高风险. 目前的指导方针不应限制PLWH糖尿病的HbA1c查,他们需要每年进行查.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 糖尿病在艾滋病毒感染者 (PLWH) 中更普遍,数据主要来自早期的艾滋病毒时代.
- 临床指南建议在抗逆转录病毒疗法 (ART) 上对PLWH进行糖尿病查.
- 在国际指南中存在差异,关于PLWH中糖尿病查的最佳血糖标志物.
研究的目的:
- 随着时间的推移,审查艾滋病毒和2型糖尿病之间的关联.
- 检查关于PLWH中的HbA1c差异的证据.
- 为PLWH提供糖尿病查的建议.
主要方法:
- 文献综述总结了关于艾滋病毒和2型糖尿病的研究.
- 对PLWH中HbA1c低估的证据分析.
- 目前国际HIV临床指南的综合.
主要成果:
- 有证据表明,HbA1c可能低估了PLWH中的血糖.
- 没有明确的依据限制基于艾滋病毒状况的糖尿病HbA1c查.
- 建议每年对PLWH进行糖尿病查,并与国家指南保持一致.
结论:
- 国际指导方针不应限制PLWH中糖尿病的HbA1c查.
- 建议每年对PLWH进行糖尿病查,这与一般人口的指导方针相一致.
- 需要进一步研究不同PLWH种群中2型糖尿病的表型和自然史.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K
Pathophysiology of Diabetes
949
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
949
Diabetes: Symptoms, Diagnosis, and Complications
554
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
554
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29


