左虚静脉刺激调节相对侧下体内β功率 改善帕金森病患者的步态
Massimo Marano1,2, Gaia Anzini1,2, Luca Saltarocchi1
1Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.
Movement disorders : official journal of the Movement Disorder Society
|December 19, 2023
概括
通过皮肤进行的耳膜迷走神经刺激 (taVNS) 通过减少大脑活动和增强运动来改善帕金森病的步态. 这种神经调节技术在管理PD步态症状方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 通过皮肤进行的迷走神经刺激 (VNS) 已在治疗帕金森病 (PD) 步行方面表现出初步的疗效.
- 需要进一步研究跨静脉VNS (taVNS) 的神经生理和临床影响.
研究的目的:
- 为了评估神经生理学和临床效应的跨静脉迷走神经刺激 (taVNS) 在帕金森病患者.
- 评估taVNS对脑下丘脑核活动和步行参数的影响.
主要方法:
- 一项试点研究采用了一种双盲,假控制的交叉设计,其中10名帕金森病患者接受深度大脑刺激 (DBS).
- 测量包括甲状腺下局部场潜力 (β带功率),统一帕金森病评级尺度 (UPDRS) 和在药物停用/DBS-OFF条件下计时启动和启动 (TUG) 测试.
- 实际与假的taVNS效应进行了比较.
主要成果:
- 左边taVNS减少了对侧面的亚thalamic核β频段功率.
- 在TUG测试时间,速度和可变性方面观察到显著的改善.
- 降低β功率与增加步行速度相关;UPDRS得分显示没有重大临床变化.
结论:
- 跨毛囊VNS (taVNS) 是一个有前途的策略,用于管理帕金森病的步态.
- 建议进行进一步的前性试验,研究taVNS的慢性神经调节.
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