集群头痛中的生物标志物:系统性审查
Marie-Louise K Søborg1, Rigmor H Jensen1,2, Mads Barloese2,3
1The Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Headache
|December 19, 2023
概括
这一系统性审查发现了集群头痛的不一致和非特异性生物标志物. 虽然一些标记物,如皮质醇和素基因相关的显示潜力,没有一个独特地识别集群头痛.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 系统审查是系统的审查.
背景情况:
- 集群头痛带来了重大的诊断和治疗挑战.
- 确定可靠的生物标志物对于诊断和治疗向至关重要.
研究的目的:
- 对集群头痛患者体液中的现有生物标志物进行系统审查.
- 评估已识别的生物标志物的诊断和病理生理学影响.
主要方法:
- 以英语,丹麦语,瑞典语或挪威语出版的同行评审研究的系统审查.
- 纳入标准:至少5名参与者,集群头痛诊断1988年后,血液,尿液,脑脊液,眼或唾液中的生物化学化合物分析.
- 在PubMed和EMBASE (2022年9月) 进行的搜索;使用纽卡斯尔-太华尺度评估偏差风险.
主要成果:
- 40项涉及832名患者和872名对照组的研究评估了80个生物标志物.
- 皮质醇 (下丘脑激素) 经常升高; 介素-1 (炎症标记物) 显示出不同的发现; 素基因相关的 (神经) 在发作期间持续升高.
- 50%的研究质量不错或很好;偏差风险的中位数为6.
结论:
- 目前对集群头痛的生物标志物研究缺乏特异性和一致性.
- 已识别的生物标志物可能反映疾病活动,但不能清楚地区分集群头痛和其他疾病.
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