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在急性缺血性中风中,应急住院血D-二聚体水平是否可以预测支架回收器血栓切除术的第一通效应?
1Department of Radiology, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu, PR China.
Acta radiologica (Stockholm, Sweden : 1987)
|December 19, 2023
概括
低血D-二聚合物水平可以预测急性缺血性中风 (AIS) 患者进行血栓切除术的成功第一通风效应 (FPE). 这一发现有助于确定大血管封闭 (LVO) 的治疗结果.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 干预性神经放射学 干预性神经放射学
背景情况:
- 血生物标志物用于识别急性缺血性中风 (AIS) 患者的第一通风效应 (FPE) 存在有限的证据,这些患者患有大血管封闭 (LVO),接受了血栓切除术.
- 准确识别FPE对于评估AIS患者治疗成功至关重要.
研究的目的:
- 评估血D-二聚物水平在LVO的AIS患者中实现FPE的预测能力.
- 为了确定D-二聚体是否可以作为FPE预测的可靠生物标志物.
主要方法:
- 分析了一组313名LVO患者的队列,这些患者接受了支架恢复器血栓切除术.
- 根据血管检查结果,患者被分为FPE (大脑梗塞[mTICI] ≥2c中的修饰性血栓溶解) 和非FPE (mTICI 0-2b) 组.
- 用物流回归和接收器运行特征 (ROC) 曲线分析来评估D-二分体的预测值.
主要成果:
- 88名 (28.1%) 患者实现了FPE.
- 与非FPE组相比,在FPE组中观察到较低的D-二聚合物水平.
- 血D-二聚合物水平 (OR=0.81),凝块负担得分和主要干封闭模式与FPE独立相关. 在ROC分析中,D-dimer的AUC值为0.761.
结论:
- 低紧急入院血D-二聚合物水平是AIS患者FPE的独立预测因子,这些患者接受了支架恢复器血栓切除术.
- 在接受血栓切除术的AIS患者中,D-二聚体提供了一个有价值的工具来预测成功的再输血.
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