固体瘤儿童的营养状况与临床结果相关:来自中国的回顾性队列研究
Yongzhen Li1,2, Zhongying Lu1, Ao Ma3
1Clinical nutrition Department, Children's Hospital of Fudan University, Shanghai, China.
Cancer medicine
|December 19, 2023
概括
在患有固体瘤的儿童中,营养不良很常见,影响了他们的治疗结果. 营养不良的儿童在医院住院时间更长,费用更高,并增加并发症的风险.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 医学成果研究研究成果
背景情况:
- 营养状况是儿童癌症治疗的关键因素.
- 关于营养变化及其对患有固体瘤的儿童的临床影响的长期数据有限.
研究的目的:
- 为了检查经过固体瘤治疗的儿童的长期营养状况变化.
- 在这个人群中调查营养状况和临床结果之间的关联.
主要方法:
- 对中国764名患有固体瘤的儿童医疗记录的回顾性审查 (2016年1月至2021年12月).
- 收集的数据包括营养状况,肠外营养,重症监护室 (ICU) 转移,感染,住院细节和费用.
- 分析的重点是营养状况的动态及其与临床结果的关系.
主要成果:
- 营养不良 (体重不足/消耗) 在诊断时影响了26.71%,在整个治疗过程中发生波动.
- 营养不良的儿童住院时间明显长 (p<0.001),住院费用较高 (p<0.001),抗生素费用增加 (p<0.001).
- 营养不良与较高的中性质衰竭风险 (OR=4.781) 和ICU转移 (OR=1.498) 有关.
结论:
- 营养不良在患有固体瘤的儿童中很普遍.
- 营养状况与不良的临床结果显著相关,包括增加的医疗保健成本和资源利用.
- 对营养状况的监测和干预对于改善儿科瘤学的结果至关重要.
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