大型β血症儿童对铁化疗法的坚持:多中心横截面研究
Thamron Keowmani1, Siew Chin Teo1, Kuan Chau Yap2
1Pharmacy Department, Hospital Wanita Dan Kanak-Kanak Sabah, Sabah, Malaysia.
Hemoglobin
|December 19, 2023
概括
马来西亚患有β-thalassemia major的儿童中,铁化疗法 (ICT) 的不坚持是普遍存在的,特别是那些服用皮下药物的儿童. 提高患者的知识和考虑给药途径可以提高对ICT的坚持.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 坚持铁化疗法 (ICT) 对于管理血症至关重要,但仍然是一个重大挑战.
- 大型β-thalassemia需要终身ICT来防止铁过载并发症.
研究的目的:
- 确定在马来西亚患有beta-thalassemia major的儿童中不遵守ICT的患病率.
- 在这个患者群体中识别与不遵守ICT相关的因素.
主要方法:
- 从2019年11月到2021年11月,在马来西亚七家三级医院进行了一项横截面研究.
- 使用药丸计数和自我报告数据,以及知识问卷来评估遵守.
- 采用决策树分析来识别不遵守的预测因素.
主要成果:
- 接受皮下±口服药物的患者中,不遵守ICT的患病率为47.5%,仅服用口服药物的患者中为21.1%.
- 关于 Thalassemia 和 ICT 的知识得分中位数为 67.5%.
- 与不遵守相关的关键因素包括ICT管理的途径和患者的知识分数.
结论:
- 与单独服用口服药物相比,在接受皮下±口服药物的儿童中,不遵守ICT的比例更高.
- 患者对血病和ICT的知识显著影响了坚持率.
- 干预措施应侧重于改善患者教育和优化ICT管理途径.
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