根据不同疫苗接种策略,比较COVID-19疫苗的免疫反应和保护作用
Tianyi Zhao1, Xiaoping Huang1, Yuelong Shu1,2
1School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China.
Human vaccines & immunotherapeutics
|December 19, 2023
概括
了解人类对呼吸道病毒的免疫反应是关键. 本综述探讨了不同的疫苗接种策略,包括增强剂和混合免疫,如何影响免疫应答和对COVID-19的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 人类拥有复杂的免疫机制来对抗高度传染性呼吸道病毒.
- 针对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的疫苗接种对于预防冠状病毒疾病2019 (COVID-19) 发病率和死亡率至关重要.
- 不断发展的COVID-19菌株需要对优化免疫策略的持续研究.
研究的目的:
- 研究免疫反应与各种疫苗接种场景的保护作用之间的关系.
- 为优化当前的疫苗接种策略提供科学基础.
- 为未来针对呼吸道病毒的疫苗的开发提供信息.
主要方法:
- 对不同疫苗接种策略的免疫反应研究的系统文献综述.
- 对接种疫苗后的幽默和细胞免疫力数据的分析.
- 评估各种免疫接种计划 (如增剂,序列,混合) 的保护作用.
主要成果:
- 不同的疫苗接种方案引起不同程度的内在,适应性,幽默性和细胞免疫.
- 增强免疫,序列免疫和混合免疫策略对抗SARS-CoV-2的保护疗效产生了明显的影响.
- 该审查综合了有关与疫苗有效性相关的免疫反应的当前知识.
结论:
- 优化疫苗接种策略需要深入了解由此产生的免疫反应.
- 对混合免疫和连续接种疫苗的进一步研究可能会增强对COVID-19的保护.
- 本综述为完善呼吸道病毒感染疫苗开发和部署提供了见解.
相关概念视频
01:51Vaccinations
44.6K
Overview
44.6K
01:29Immune Response Against Viral Pathogens
789
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
789
01:23Immunological Memory
624
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
624
00:42Cross-reactivity
31.1K
Overview
31.1K
01:31Active versus Passive Immunity
652
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
652
01:30Cancer Vaccines
376
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
376