免疫检查点抑制剂疗效的循环生活方式决定因素
Bethan R Hughes1,2, Sadiq Shanaz1, Seline Ismail-Sutton1
1Oncology Department, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor, United Kingdom.
Frontiers in oncology
|December 19, 2023
概括
优化癌症免疫疗法 (ICI) 需要了解生活方式因素. 本综述探讨了昼夜节律和日常习惯如何增强患者对免疫检查点抑制剂的反应.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但许多患者无法获得最大的益处.
- 关于ICI抗性/反应的研究主要集中在免疫和癌症机制上,对可修改的生活方式因素的关注较少.
- 新出现的证据表明,一天中的某个时间给予ICI会影响患者的治疗结果.
研究的目的:
- 批判性地审查现有的临床和实验证据对可修改的生活方式因素及其对ICI疗效和耐受性的影响.
- 探索昼夜计时系统在调解生活方式因素和免疫反应中的作用.
- 通过生活方式干预提出改善癌症免疫治疗结果的策略.
主要方法:
- 对当前的临床和实验数据进行系统的审查和批判性合并.
- 对昼夜节律对免疫系统功能影响的分析.
- 调查生活方式因素 (饮食,运动,睡眠,暴露于光线) 以及它们与微生物群的相互作用.
主要成果:
- 昼夜时钟会影响免疫系统的活动和对治疗的反应.
- 根据昼夜节律定时的生活方式因素可以调节免疫反应.
- 微生物组是一个新兴的调解者,受到生活方式的影响,并可能影响免疫治疗.
结论:
- 可修改的生活方式因素,当与昼夜时间调整一致时,为提高癌症免疫疗法的有效性提供了一个有希望的途径.
- 个性化慢性疗法和生活方式干预措施可以优化患者的治疗结果.
- 需要进一步的研究来阐明昼夜生物学,生活方式,微生物组和免疫治疗之间的复杂相互作用.
相关概念视频
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
64
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
64
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
01:19Factors Affecting Drug Biotransformation: Biological
153
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
153
01:27Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
01:27Cytotoxic T Cells-mediated Immune Response
923
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
923