爬行脂肪在克罗恩病中表现出明显的炎症特异性脂肪原性前脂肪细胞
Nahee Hwang1,2,3, Dongwoo Kang4, Su-Jin Shin5
1Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Frontiers in immunology
|December 19, 2023
概括
克罗恩病中的爬行脂肪涉及特定的前脂肪细胞变化,导致炎症和纤维化. 向素-3可能为这种疾病提供新的治疗途径.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 爬行脂肪 (CrF),介质脂肪组织积累,与克罗恩病 (CD) 炎症和纤维化有关.
- 人们对CRF导致CD纤维化的确切机制尚不清楚.
- 了解CRF细胞和分子动态对于开发向疗法至关重要.
研究的目的:
- 通过单细胞RNA测序,全面分析CRF的转录基因格局.
- 为了比较CrF与其他疾病的脂肪组织,如性结肠炎,淋巴和肥胖症.
- 确定细胞参与者和参与CRF相关炎症和纤维化中的分子通路.
主要方法:
- 来自克罗恩病患者中介质脂肪组织的单细胞RNA测序.
- 用性结肠炎,淋巴和肥胖症队伍的脂肪组织进行比较性转录组分析.
- 生物信息分析用于识别细胞群,基因表达模式和细胞-细胞通信.
主要成果:
- 在CRF中确定了两种前脂细胞 (PAC) 血统,一种与脂肪生成有关,另一种与纤维化有关.
- 在CrF中进行的PACs表现出增加的细胞因子表达和纤维活性,由细菌刺激加剧.
- 在CrF中观察到亲纤维性PAC中素-3表达的增加和IgG+血细胞透的增加.
结论:
- 冠状炎症涉及不同的PAC种群,有助于克罗恩病的炎症和纤维化.
- 在PAC中升级的素-3和增加的IgG+血细胞表明了CRF纤维化潜在的治疗点.
- CrF表现出独特的细胞-细胞通信配置文件,特别是涉及MIF,与其他条件不同.
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