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Updated: Jul 8, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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AML通过Notch信号改变了骨髓 stromal 细胞的骨质承诺

Chiara Tomasoni1, Corinne Arsuffi1, Samantha Donsante1,2

  • 1Tettamanti Center, Fondazione Istituto Ricovero e Cura a Carattere Scientifico (IRCCS) San Gerardo dei Tintori, Monza, Italy.

Frontiers in immunology
|December 19, 2023
PubMed
概括

急性髓性白血病 (AML) 细胞通过Notch信号破坏骨髓 stromal 细胞 (BMSCs) 的骨质分化. 这通过促进骨质前细胞积累,创造了一个支持白血病的利基.

关键词:
在AML的利基市场.骨髓干细胞 (BMSCs) 是指骨髓的干细胞.口信号传输是没有的.急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.骨质发生过程 (osteogenesis)

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