怀孕期间改变的饮食行为会影响系统代谢表型
Charlotte E Rowley1, Samantha Lodge1, Siobhon Egan1
1Australian National Phenome Centre, and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia.
坚持地中海饮食 (MD) 的孕妇表现出明显的代谢特征,炎症标志物较低. 这种饮食模式与特定的肠道微生物代谢物有关,为围产期健康提供了洞察力.
科学领域:
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
- 孕产妇健康 孕产妇健康
背景情况:
- 地中海饮食 (MD) 与积极的母亲和后代健康结果有关.
- 炎症通路是MD的健康益处的潜在调解者.
- 了解怀孕期间饮食坚持的代谢影响对于围产期健康至关重要.
研究的目的:
- 为了比较孕妇的新陈代谢概况,高与低的坚持MD.
- 研究MD坚持,代谢表型和炎症标志物之间的关系.
- 确定潜在的生物标志物来评估怀孕期间的健康风险.
主要方法:
- 利用ORIGINS队列,根据MD的坚持分层51名孕妇.
- 在妊娠36周使用1H核磁共振 (NMR) 光谱测定血清和尿液代谢概况.
- 分析了饮食模式,代谢物概况和炎症状态之间的相关性.
主要成果:
- 在高 (HMDA) 和低 (LMDA) MD坚持群体之间的食物选择和代谢概况中观察到显著差异.
- 在HMDA组,尿液中尿酸含量较高,肌酸含量较低,与减少肉类摄入量和增加蔬菜摄入量有关.
- HMDA组显示较低的血清炎症生物标志物 (GlycA,GlycB) 和与植物性营养素的关联;LMDA组显示与分支链氨基酸和肌酸的关联.
结论:
- 怀孕期间的高MD坚持与独特的代谢表型有关,与报告的食物摄入量保持一致.
- 代谢差异突出显示了系统性炎症和肠道微生物代谢物的显著变化.
- 研究结果为围产期健康机制提供了新的见解,并确定了风险评估的潜在生物标志物.
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