布雷克西普拉在患有精神分裂症的患者中,有或没有物质使用障碍:一项观察性研究
Ginevra Lombardozzi1, Giada Trovini1, Emanuela Amici1
1Villa Von Siebenthal Neuropsychiatric Hospital and Clinic, Genzano di Roma, Italy.
Frontiers in psychiatry
|December 19, 2023
概括
布雷克西普拉能有效地治疗成年人的精神分裂症症状,不论是药物使用障碍 (SUD) 的并发症. 这种部分多巴胺D2激动剂也减少了SUD患者的渴望.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 部分多巴胺D2受体激动剂是精神分裂症中精神病症状的确立治疗方法.
- 新兴研究探讨了它们在治疗物质使用障碍 (SUD) 中的有效性.
- 精神分裂症患者有SUD可能会因为他们的精神疾病而治疗效率降低.
研究的目的:
- 评估布雷克斯皮普拉在精神分裂症患者和没有并发性SUD患者的疗效.
- 评估布雷克斯皮普拉对精神分裂症和SUD患者物质渴望的影响.
主要方法:
- 一项为期6个月的开放性研究,涉及86名精神分裂症患者 (48名SUD,38名没有).
- 这些患者每天接受布雷克斯皮普拉4毫克的治疗.
- 使用CGI-S,BPRS和PANSS评估症状严重程度;用VAScrav.测量物质渴望.
主要成果:
- 布雷克西普拉在6个月内在SUD和非SUD组中显著改善了精神病症状 (CGI-S,BPRS,PANSS).
- 在SUD和非SUD组之间,精神症状的改善是可比的.
- 在SUD组中,物质渴望 (VAScrav) 显著下降.
结论:
- 布雷克西普拉在治疗精神分裂症症状方面是有效的,不论SUD的并发症.
- SUD并发症似乎没有降低布雷克斯皮普拉在精神分裂症的疗效.
- 布雷克西普拉表明,它有潜力减少精神分裂症患者的物质渴望.
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