睡眠质量差与更高的肺癌风险相关:一项嵌套病例对照研究
Guo-Tian Ruan1,2,3, Ya-Ping Wei4, Yi-Zhong Ge1,2,3
1National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China.
PeerJ
|December 19, 2023
概括
睡眠质量差与患肺癌的风险更高有关. 睡眠不足的吸烟者面临的风险更大,这凸显了解决睡眠问题的重要性,以预防肺癌.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠质量与肺癌发病率之间的关系尚不清楚.
- 调查这种联系对于公共卫生和预防策略至关重要.
研究的目的:
- 检查睡眠质量与患肺癌的风险之间的联系.
- 为了确定吸烟状态是否会改变这种关系.
主要方法:
- 通过使用Lianyungang队列的数据进行了一项嵌套病例控制研究.
- 分析了150例肺癌病例和150个匹配的对照.
- 采用了单变量和多变量逻辑回归模型.
主要成果:
- 睡眠质量差与肺癌风险增加显著相关 (OR=1.83,P=0.033).
- 分层分析显示,吸烟者睡眠质量差与癌症风险之间存在较强的正相关性.
- 睡眠质量差的吸烟者患肺癌的发生率比睡眠质量好的非吸烟者高2.79倍.
结论:
- 睡眠质量差是增加肺癌发病率的重要危险因素.
- 吸烟和睡眠质量差的结合大大提高了肺癌的风险.
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