睡眠不足与运动:一场决斗来决定疼痛是否会消失或在受伤后持续存在
David M Klyne1, Brendan A Hilliard2, Michele Y Harris2
1NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, 4072, Australia.
Brain, behavior, & immunity - health
|December 19, 2023
概括
睡眠不足可能使急性疼痛恶化为慢性疼痛. 然而,有氧运动可以帮助预防这种过渡并减少疼痛,可能通过脑衍生神经营养因子 (BDNF) 途径.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 运动生理学 运动生理学
背景情况:
- 睡眠不足与增加疼痛敏感性有关.
- 众所周知,有氧运动通过各种机制减轻疼痛.
- 睡眠,运动和疼痛慢性化之间的相互作用仍然不清楚.
研究的目的:
- 调查睡眠不足是否有助于急性损伤导致持续疼痛的发展.
- 为了确定运动是否可以防止这种从急性疼痛过渡到持续性疼痛.
- 在这种关系中探索潜在的生物机制,包括来自大脑的神经营养因子 (BDNF).
主要方法:
- 建立了急性过度使用损伤的受控老鼠模型.
- 鼠被 subjected to自愿运动,睡眠障碍,或两个干预措施.
- 测量了疼痛行为,BDNF,雌激素,皮质和白细胞.
主要成果:
- 睡眠障碍单独维持了受伤后疼痛敏感度的升高.
- 运动使疼痛敏感度正常化,无论睡眠状况如何.
- 运动促进了握力恢复,BDNF水平与疼痛敏感性相关.
结论:
- 睡眠不足可能在从急性疼痛过渡到持续性疼痛中起作用.
- 有氧运动显示出对抗睡眠中断疼痛的潜力.
- 在睡眠,运动和疼痛之间的关系中,BDNF可能是一个关键的调解者.
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