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一个探索性研究对异常思维在肌缩侧面硬化症的探索性研究

Barbara Poletti^1,2, Edoardo Nicolò Aiello¹, Sofia Tagini³

¹Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy.

Frontiers in psychology

|December 19, 2023

概括

肌缩性侧面硬化症 (ALS) 患者的反事实思维 (CFT) 与口语流和记忆相关. CFT测量有效地将ALS患者与健康对照区分开来.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
神经学神经学

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元.
认知障碍在ALS中很常见,影响包括执行功能在内的各种领域.
反事实思维 (CFT) 涉及考虑替代可能性,可能会受到ALS认知变化的影响.

研究的目的:

调查非痴呆ALS患者中CFT能力的运动和非运动相关物.
评估CFT测量对区分ALS患者与健康对照 (HCs) 以及具有不同认知特征的ALS患者的疗效.

主要方法:

一组110名ALS患者和51名HC患者完成了两个CFT任务,得分汇总成CFT指数 (CFTI).
患有ALS的患者使用爱丁堡认知和行为ALS屏幕 (ECAS) 进行了全面的认知,行为和运动评估.
相关性分析检查了CFTI相关性,后勤回归测试了它的区分能力.

主要成果:

CFTI与ECAS的口语流性和记忆子表显著相关 (p ≤ 0.005).
在区分ALS患者和HC患者 (p < 0.001) 中,CFTI得分显示出高准确度 (82%).
在ECAS-Total上,CFTI没有显著区分ALS患者的正常与受损表现.

结论:

非痴呆性ALS患者的CFT能力与特定的认知功能有关,即语言流性和记忆力.
CFT措施是区分患有ALS的人与健康对照的有价值的工具.

关键词:

骨髓缩侧面硬化症 (ALS) 是一种认知认知认知反事实性思维是一种反事实性思维.痴呆症痴呆症是一种痴呆症.前退行症前退行症神经心理学神经心理学

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