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监督的运动训练在癌症患者在以环素为基础的化疗缓解心脏毒性:一个随机对照试验

Caroline Schneider^1,2, Christoph Ryffel³, Laura Stütz¹

¹Centre for Rehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Frontiers in cardiovascular medicine

|December 19, 2023

概括

在人环素化疗 (AC) 期间监督的运动训练在预防心脏损伤方面并没有显著超过活动追踪器. 然而,身体活动显示了与心脏保护作用的剂量反应关系,这表明它对接受AC的患者的建议.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
运动生理学运动生理学

背景情况:

基于人环素的化疗 (AC) 可以引起心脏毒性,这是已知的副作用.
动物模型表明,运动训练 (ET) 可以减轻这种心脏毒性.
癌症患者的强有力的临床试验数据仍然有限.

研究的目的:

评估在AC期间监督ET在预防心脏毒性的有效性.
为了比较ET在AC期间与ET在AC后对心脏功能和生物标志物的影响.
探索身体活动 (PA) 和心脏保护作用之间的关联.

主要方法:

一项随机对照试验,涉及57名患有乳腺癌或淋巴瘤的患者接受AC.
参与者在AC期间被分配到ET (EXduringAC) 或仅使用活动追踪器 (EXpostAC).
主要结局是左心室全球纵向应变 (GLS);次要结局包括hsTnT,NT-proBNP,峰值VO2和客观测量的PA.

主要成果:

在AC结束时,GLS在两组都恶化,EXduringAC和EXpostAC之间没有显著差异.
在两组中都观察到hsTnT和NT-proBNP的增加,没有跨组差异.
在聚合分析中,中度至强度的PA (MVPA) 与更好的GLS和较低的hsTnT增加显著相关.

结论:

在AC期间监督ET在这个小RCT中在减轻心脏毒性方面并不优于活动跟踪.
观察到PA和心脏保护作用之间的剂量反应关系.
对接受AC的患者应建议进行体力活动.

关键词:

加速测量仪加速测量仪生物标志物生物标志物心脏有毒性心脏有毒性运动训练运动训练运动训练全球纵向菌株全球纵向菌株身体活动跟踪跟踪

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