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基于纳米粒子的输送平台,用于增强/蛋白质的口服输送
Sara Salatin1, Soheila Montazersaheb2, Afsaneh Farjami3,4
1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Therapeutic delivery
|December 19, 2023
概括
由于分子大小和稳定性,口服/蛋白质药物面临着挑战. 纳米颗粒 (NP) 显示出作为这些生物制药的有效输送系统的承诺,改善了口服的管理.
科学领域:
- 生物制药药物的药物开发.
- 药物输送系统是药物输送系统.
- 纳米技术在医学中的应用
背景情况:
- 和蛋白质药物是具有广泛治疗潜力的现代生物制药的重要类别.
- 腹腔注射是传统的途径,但口服提供了一个非侵入性的替代方案.
- 口服/蛋白质输送的挑战包括高分子量,稳定性差,口服生物可用性低.
研究的目的:
- 审查纳米颗粒 (NP) 作为/蛋白质药物的输送系统的应用.
- 评估NP在促进这些治疗药物的有效口服输送方面的有效性.
主要方法:
- 关于基于纳米粒子的药物递送系统的文献综述.
- 分析了使用NP进行口服输送和蛋白质的研究.
- 评估与克服口服分娩障碍相关的NP特征.
主要成果:
- 纳米粒子在克服口服/蛋白质输送的局限性方面表现出显著的潜力.
- 国家药物可以提高/蛋白质药物的稳定性和生物分布.
- 通过使用各种NP配方,成功地通过口服输送治疗性和蛋白质.
结论:
- 纳米颗粒是口服/蛋白质生物制药的有希望的策略.
- 对基于NP的系统的进一步研究可以推进非侵入性治疗选择.
- 优化的NP配方是释放口服/蛋白质药物递送的全部潜力的关键.
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