高血压诊断时性别差异与年龄的关联与大脑结构
Amanpreet Kaur1,2, Adriana Angarita Fonseca2, Rikki Lissaman3,4
1Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.).
Hypertension (Dallas, Tex. : 1979)
|December 19, 2023
概括
高血压会根据性别和诊断年龄不同地影响大脑结构. 患有高血压的年轻男性显示大脑体积减少,而老年女性则有更多的白质超强度,表明对大脑小血管疾病的性别特异性影响.
科学领域:
- 神经学 神经学
- 心血管健康 心血管健康
- 医疗成像医学成像
背景情况:
- 性差异影响认知能力下降的风险.
- 高血压诊断年龄独特地影响与大脑小血管疾病相关的大脑结构.
- 高血压诊断年龄对大脑结构的性别特异性影响尚不清楚.
研究的目的:
- 调查高血压诊断时的年龄与大脑小血管疾病相关的大脑结构变化之间的性别差异.
主要方法:
- 利用了英国生物库数据 (n=9430),包括高血压诊断年龄和脑部MRI.
- 按性别和高血压诊断年龄分层参与者,使用对照的倾向性得分匹配对照.
- 采用了对形态变化的通用线性模型和对白质微观结构的回归的主要成分分析.
主要成果:
- 年轻时被诊断患有高血压的男性的灰色和白质体积比对照人群低.
- 患有高血压的两种性别都显示出白质强度增加,特别是在老年女性中.
- 高血压降低了白质的微观结构完整性,随着年龄的增长而恶化.
结论:
- 高血压对大脑小血管疾病相关的大脑结构的影响因性别而异.
- 高血压诊断时的年龄是调节这些性别特异性对大脑结构影响的关键因素.
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