ICTV病毒分类简介:金丘维拉莱斯2023年
Jens H Kuhn1, Nolwenn M Dheilly2, Sandra Junglen3
1Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
The Journal of general virology
|December 19, 2023
概括
京丘维拉是负感RNA病毒,在全球范围内在不同的宿主中发现. 本报告总结了国际病毒分类学委员会关于这种病毒序列及其家族的发现.
科学领域:
- 病毒学 病毒学
- 分类学 分类学是指分类学.
- 基因组学就是基因组学.
背景情况:
- 京丘维拉群是负感RNA病毒的一类.
- 这些病毒的基因组大小从9.1到15.3kb不等.
- 它们与各种各样的宿主有关,包括无脊椎动物和脊椎动物在所有有人居住的大陆.
研究的目的:
- 要总结国际病毒分类学委员会 (ICTV) 关于金丘维拉群的报告.
- 为了提供一个概述的家庭在Jingchuvirales顺序:阿里乌斯维里,Chuviridae,Crepuscuviridae,米利亚维里,和纳塔维里.
主要方法:
- 这项研究是基于ICTV官方的报告.
- 这些信息来自于Jingchuvirales的可用基因组序列.
- 该报告整合了分类学信息和基因组特征.
主要成果:
- 京丘病毒基因组通常包含两到四个开放的读取框架 (ORF).
- 这些ORF编码必要的病毒蛋白,如糖蛋白 (GP),核蛋白 (NP) 和RNA导向RNA聚合酶 (RdRP).
- 目前,这种序列中的病毒仅从它们的基因组序列中知道.
结论:
- 该ICTV报告提供了一个全面的对Jingchuvirales秩序的分类学框架.
- 这种分类包括五个家族:阿里乌斯维里idae,丘维里idae,克雷普斯库维里idae,米利亚维里idae和纳塔维里idae.
- 进一步的研究可能会阐明未知的蛋白质的功能,并扩大我们对这些病毒的理解.
相关概念视频
What are Viruses?
115.0K
Overview
115.0K
Viral Structure
62.3K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.3K
Viral Recombination
23.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K
Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K
Viral Mutations
32.3K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.3K
Retroviruses
12.3K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.3K


