来自四个模型的定量扩散指标的稳定性:关于扫描-再扫描,voxel大小,线圈和观察者的影响的前性研究
Jingyu Zhong1, Xianwei Liu1, Yangfan Hu1
1Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of magnetic resonance imaging : JMRI
|December 19, 2023
概括
伏塞尔大小显著影响了定量扩散MRI指标的可重复性,而不是扫描-重新扫描或线圈类型. 对于这些扩散指标,观察者内部的协议优于观察者间的协议.
科学领域:
- 神经成像是一种神经成像.
- 医学物理 医学物理
- 放射学 放射学是一门学科.
背景情况:
- 定量扩散指标为疾病提供了有价值的微观结构见解.
- 确定这些指标的稳定性对于其临床采用至关重要.
研究的目的:
- 评估定量扩散磁共振成像 (MRI) 指标的可变性和可重复性.
- 确定影响扩散MRI指标稳定性的因素.
主要方法:
- 这是一项前性研究,涉及14名健康志愿者,接受了重复的3.0特斯拉扩散光谱成像 (DSI).
- 在每个受试者的四个扫描过程中,引入了线圈类型和voxel大小的变化.
- 13个大脑区域的观察者内部和观察者间可重现性被评估,使用了类内相关系数 (ICC) 和一致性相关系数 (CCC).
主要成果:
- 定量扩散指标表现出变化,变化系数 (CV) 从2.4%到68.2%不等.
- 与较小的voxels (2x2x2 mm3) 和优化线圈使用相比,更大的voxel大小 (3x3x3 mm3) 和某些线圈组合的可复制性明显较差.
- 观察者内部可重复性 (ICC:0.49-0.94) 始终高于观察者之间的可重复性 (ICC:0.28-0.91).
结论:
- 伏塞尔大小对定量扩散MRI指标的可重现性产生了更大的影响,而不是扫描-重新扫描协议或线圈配置.
- 与不同观察者之间相比,在单个观察者内观察到更高的可重复性,这突显了标准化协议的重要性.
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