免疫学障碍和结肠失调症在肥胖的患者与甲状腺功能低下症
Yelyzaveta S Sirchak1, Mikola M Voloshin1, Ivan I Kohutych1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
患有甲状腺功能低下的肥胖患者表现出肠道细菌和免疫反应的改变,包括免疫球蛋白的增加和有益细菌的减少. 这些变化与胃肠道症状和免疫状态受损相关.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖与改变的肠道微生物群和免疫失调有关.
- 甲状腺功能低下症可以进一步加剧这些代谢和免疫学障碍.
研究的目的:
- 调查免疫变化及其与肥胖患者的甲状腺功能低下症 (HT) 结肠失调的相关性.
主要方法:
- 在48名患有HT的肥胖患者和34名没有HT的肥胖患者的便分析和补充剂 (C3,C4) 和免疫球蛋白 (IgA,IgM,IgG) 的染色体分析.
- 对胃肠道症状进行临床检查.
主要成果:
- 患有HT的肥胖患者报告了更多的便秘和膨胀. 没有HT的肥胖患者表现出对腹的倾向.
- 两组人都表现出免疫状况的改变,血清IgA,IgM和IgG水平增加.
- 患有肥胖和HT的患者显示Bifidobacterium和Lactobacillus的数量下降,Staphylococcus,Clostridium,Proteus和Klebsiella的数量增加.
结论:
- 肥胖,特别是甲状腺功能低下,与显著的肠道失调有关,其特点是有益细菌减少和致病细菌增加.
- 甲状腺功能低下症和肥胖症共同导致明显的免疫功能障碍,包括免疫球蛋白升高和补体水平降低 (C3,C4).
- IgA和IgG的水平直接取决于肥胖患者的肠道微生物失衡,这种现象在患有同时存在的甲状腺功能低下症患者中更为明显.
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