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Updated: Jul 8, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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通过自-结化合物在活体中向降解PCSK9

Zhirong Ouyang1, Muye Ma2, Ziwen Zhang1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201301, China.

Journal of medicinal chemistry
|December 19, 2023
PubMed
概括

新的自细胞结合化合物 (ATTEC) 降解蛋白转化酶亚素/素类型-9 (PCSK9). 化合物OY3有效降低LDL-C,改善动脉样硬化,甚至可以增强他类药物治疗.

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