年龄,APOE和常见的环境风险因素对人类大脑结构的相互作用影响
Jie Chen1, Tengfei Li2,3, Bingxin Zhao4
1Department of Biostatistics, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill NC 27514, United States.
Cerebral cortex (New York, N.Y. : 1991)
|December 19, 2023
概括
大脑衰老因遗传学和生活方式而有很大差异. 这项研究揭示了年龄,性别,APOE基因型和生活方式等因素如何相互作用,影响大脑结构和健康.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 大脑衰老表现出由遗传和环境因素影响的多种轨迹.
- 这些多样化的大脑衰老模式背后的机制在很大程度上仍然不清楚.
- 了解这些影响对于解决与年龄相关的认知衰退至关重要.
研究的目的:
- 调查大脑结构措施与各种风险因素之间的关联.
- 检查年龄,性别,遗传因素 (APOE,多基因风险得分) 和生活方式对大脑衰老的相互作用.
- 为了确定有助于明显的大脑衰老模式的特定相互作用效应.
主要方法:
- 利用了来自36969名参与者 (44-81岁) 的英国生物库数据.
- 评估的大脑体积,白质扩散性,阿波利波蛋白E (APOE) 基因型,多基因风险得分,生活方式因素和社会经济地位.
- 进行了全面的关联分析,包括与年龄和性别的相互作用影响.
主要成果:
- 确定了726个显著的关联信号,其中教育,酒精和吸烟影响了大多数大脑区域.
- 发现了显著的相互作用:年龄-APOE-ε4 (负) 和年龄-APOE-ε2 (阳性) 对杏仁体体积的影响,特别是在女性身上.
- 观察到年龄-性别-APOE-ε4对小脑体积的相互作用,年龄-过度-酒精对白质扩散性的相互作用,以及对半中心体积的年龄-饮食相互作用.
结论:
- 大脑衰老是由年龄,性别,遗传 (APOE) 和环境因素 (生活方式) 之间的复杂相互作用形成的.
- 特定的相互作用,例如与APOE基因型和酒精消费,显著影响大脑结构.
- 考虑这些联合影响的整体方法对于理解正常和异常的大脑衰老至关重要.
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