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Updated: Jul 8, 2025

Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons

Published on: August 6, 2014

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内生mRNA驱动和空间封闭衍生的DNA纳米机器用于Let-7a的超快速和敏感成像

Yinghui Feng1, Shenghong Liu1, Yao Yao1

  • 1College of Chemistry and Chemical Engineering, the Hunan Provincial Key Laboratory of Water Environment and Agriculture Product Safety, Central South University, Changsha 410083, Hunan, China.

Analytical chemistry
|December 19, 2023
PubMed
概括

这项研究开发了一个DNA纳米生物传感器,用于敏感的细胞内miRNA成像. 新的设计增强了信号放大和稳定性,用于潜在的临床诊断.

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High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays MEA

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相关概念视频

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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