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患有原发性髓性甲状腺癌的患者远程转移的风险因素分析:基于人口的研究

Hang Su^1,2, Quancang Men¹, Juanjuan Hao³

¹Department of Thyroid and Breast Surgery, Hebei General Hospital, Shijiazhuang, China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|December 19, 2023

概括

年轻或年长的年龄,黑人种族和晚期瘤阶段是髓性甲状腺癌中远程转移的关键风险因素. 识别这些因素有助于对高风险患者进行早期干预.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
癌症流行病学癌症流行病学

背景情况:

骨髓性甲状腺癌 (MTC) 的特点是具有显著的复发倾向和远程转移.
准确识别远程转移的风险因素对于有效的患者管理和预后至关重要.

研究的目的:

研究和确定与原发性髓性甲状腺癌的远程转移相关的独立风险因素.

主要方法:

使用SEER数据库对685名在2010-2015年间被诊断为原发性髓性甲状腺癌的患者进行了回顾性分析.
对患者人口统计和瘤临床病理特征的评估.
使用单变量和多变量逻辑回归分析来确定远程转移的独立风险因素.

主要成果:

在5.84%的研究患者中观察到远程转移.
多变量分析确定年龄 (≤18或>55岁),黑人种族,较高的pT阶段和较高的N阶段作为远程转移的独立风险因素.
诸如婚姻状况,性别,多焦点疾病和囊透等因素在单变量分析中显示出显著的相关性,但不是独立的预测因素.

结论:

年龄极端 (≤18或>55岁),黑人种族,先进的pT阶段和先进的N阶段与MTC中远程转移的风险增加显著相关.
这些发现使临床医生能够主动识别和监测患有远程转移性疾病风险较高的患者,促进及时的治疗策略.

关键词:

遥远的转移遥远的转移骨髓甲状腺癌是一种甲状腺癌.转移性模式转移性模式风险因素风险因素风险因素

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