维生素D缺乏与SARS-CoV-2感染后急性结果之间的关联
Jheng-Yan Wu1,2,3, Mei-Yuan Liu1,4,5,6, Wan-Hsuan Hsu7
1Department of Nutrition, Chi Mei Medical Center, Tainan, Taiwan.
European journal of nutrition
|December 19, 2023
概括
在COVID-19患者中,维生素D缺乏 (VDD) 与急诊,住院和在后急性阶段死亡的风险增加有关. 这一发现强调了监测严重急性呼吸综合征冠状病毒2感染后康复的个体维生素D水平的重要性.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏 (VDD) 很普遍,可能会影响免疫功能.
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染可能导致持续的后急性症状.
- 在SARS-CoV-2感染后,VDD与长期结果之间的关系需要进一步调查.
研究的目的:
- 检查SARS-CoV-2感染患者维生素D缺乏和急性后结果之间的关联.
- 为了评估后COVID-19条件的风险,与对照组相比,VDD患者的急诊室访问,住院和死亡率.
主要方法:
- 使用TriNetX研究网络进行了一项回顾性研究.
- 包括2022年1月1日至11月30日期间诊断的COVID-19患者.
- 倾向性得分匹配 (PSM) 用于创建VDD (<20 ng/mL) 和对照 (≥20 ng/mL) 患者的匹配组.
主要成果:
- 该研究包括8300名VDD患者和8300名匹配对照.
- VDD组表现出复合初级结果 (急诊室访问,住院,死亡) 的风险明显更高 (HR=1.122;95% CI=1.041-1.210).
- 具体来说,VDD与所有原因的ED访问 (HR=1.114),住院 (HR=1.230) 和死亡 (HR=1.748) 的风险增加有关,但不是COVID-19后的情况 (HR=0.980).
结论:
- 维生素D缺乏可能与SARS-CoV-2感染后不良后急性结果的风险增加有关.
- 这些结果包括所有原因的急诊室访问,住院和死亡率的增加.
- 需要进一步的研究来阐明因果机制和潜在的干预措施.
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