单氨基网络功能障碍和多发性硬化症中抑郁症的发展:纵向调查
Damiano Mistri1, Paola Valsasina1, Loredana Storelli1
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Journal of neurology
|December 19, 2023
概括
多发性硬化症 (MS) 中的抑郁症与大脑网络的变化有关. 这项研究发现,在MS患者中发展抑郁症状与多巴胺和上腺素网络的休息状态功能连接性 (RS FC) 随着时间的推移而降低相关.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 精神病学是一个精神病学.
背景情况:
- 多发性硬化症 (MS) 中的抑郁症通常与单氨基网络的功能障碍有关.
- 调查这种联系及其神经支的纵向研究很少.
研究的目的:
- 调查MS患者抑郁症状的发展与单氨基基网络中的静止状态功能连接 (RS FC) 变化之间的关联.
- 探索RS FC的纵向变化及其与抑郁症状严重程度的相关性.
主要方法:
- 49名多发性硬化患者和27名健康对照人接受了基线和随访RS FC评估 (中位数为1.6年).
- 与单胺相关的RS FC是使用独立组件分析衍生出来的,该分析受限于多巴胺,诺亚上腺素和血清素载体的PET图谱.
- 分析了RS FC的纵向变化及其与蒙哥马利-阿斯伯格抑郁量表 (MADRS) 评分的相关性.
主要成果:
- 在基线时,与对照组相比,多发性硬化患者在正面,带膜,小脑和脑脊部区域表现出改变的RS FC.
- 患有抑郁症状 (D-MS) 的MS患者随着时间的推移,多巴胺和上腺素网络RS FC显著下降.
- 在这些网络中,RS FC的降低与MADRS得分的增加显著相关 (r = -0.65至 -0.61,p < 0.001).
结论:
- 多发性硬化中抑郁症状的发展与多巴胺和上腺素网络内的RS FC的特定纵向变化有关.
- 这些发现强调了单氨基网络改变在MS抑郁症病理生理学的作用.
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