基于OMIC科学的个性化营养计划与超重和肥胖成年人的一般营养计划的经济评估:基于丹麦试验数据的建模研究
Milanne Maria Johanna Galekop1, Carin Uyl-de Groot2, William Ken Redekop2
1Erasmus Universiteit Rotterdam, Erasmus School of Health Policy and Management, Rotterdam, The Netherlands. galekop@eshpm.eur.nl.
PharmacoEconomics - open
|December 19, 2023
概括
个性化营养计划对预防肥胖没有显著的短期益处,并且可能不具有成本效益. 降低干预成本可以提高成本效益,但需要进行更大规模的试验来确认有效性.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 营养科学 营养科学
背景情况:
- 个性化营养 (PP) 在预防肥胖方面越来越受欢迎.
- 关于PP的有效性和成本效益的证据对于资助决策至关重要.
- 这项研究评估了与丹麦的非个性化计划相比,新型PP的成本效益.
研究的目的:
- 评估个性化营养计划 (PP) 与非个性化计划的终身成本效益.
- 根据个人营养方法的资助和实施做出决策.
主要方法:
- 一个为期10周的随机对照试验与经过验证的肥胖经济模型相结合.
- 干预组接受了个性化的餐饮和行为信息;对照组接受了非个性化的版本.
- 使用多状态马尔科夫模型估计的终身成本效益,考虑社会成本和质量调整后的寿命年 (QALYs).
主要成果:
- 短期内,PP和对照组之间的有效性 (BMI,生活质量) 没有显著差异.
- PP将终身成本增加了1736欧元,QALY增加了0.011,导致每QALY获得的158,798欧元的高增量成本效益比率 (ICUR).
- 干预成本减少20%可以将ICUR降至每QALY23,668欧元,低于基于GDP的支付意愿门.
结论:
- 根据目前的数据和支付意愿值,PP可能不具有成本效益.
- 扩大干预可以降低成本,提高成本效益.
- 未来的研究需要更大和/或更长的研究,以减少关于短期有效性的不确定性.
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