局部应用抗生素预防的药理动力学,用于植入基乳房重建
Mathilde Nejrup Hemmingsen1, Anne Karen Bennedsen1, Randa Bismark Kullab1
1Department of Plastic Surgery and Burns Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
JAMA network open
|December 19, 2023
概括
乳腺植入物的三重抗生素灌提供了足够的预防性预防黄金葡萄球菌. 然而,对Pseudomonas aeruginosa的保护可能不足,这表明需要进一步研究乳腺重建的抗生素预防.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 药理动力学 药理动力学
背景情况:
- 乳房植入物的抗生素灌是全球普遍的做法.
- 没有先前的临床研究检查了乳房植入物口袋内的抗生素预防的药理动力学.
研究的目的:
- 为了确定局部应用的 جنت米辛,塞法索林和万科米辛度在乳房植入物口袋中超过最小抑制度 (MIC) 的持续时间.
- 评估当地的灌后这些抗生素的系统吸收.
主要方法:
- 一项前性队列研究,涉及40名接受植入式乳房重建的患者.
- 患者接受了三重抗生素灌 (仁胺素,塞法索林,万科米辛) 或安慰剂.
- 从手术排水和血液中采集了最多10天的术后样本,以测量抗生素度.
主要成果:
- 旺科米辛和塞法索林的度保持在Staphylococcus aureus的MIC以上,比 جنت米辛更长的时间.
- 亨塔米辛在Pseudomonas aeruginosa的MIC上方保持了1.3天.
- 在血液样本中检测到Cefazolin的度非常低;其他抗生素没有系统检测到.
结论:
- 三重抗生素灌提供了足够的预防黄金葡萄球菌和其他常见的与乳腺植入物相关的グラム阳性细菌.
- 对Pseudomonas aeruginosa的疗效可能不足,这表明当前预防策略的潜在局限性.
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