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Updated: Jul 8, 2025

Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells
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咖啡:对单细胞染色质可访问性数据的基于相关性特征选择

Keyi Li1, Xiaoyang Chen1, Shuang Song2

  • 1Ministry of Education Key Laboratory of Bioinformatics, Bioinformatics Division at the Beijing National Research Center for Information Science and Technology, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.

Briefings in bioinformatics
|December 19, 2023
PubMed
概括

我们开发了Cofea,这是一种分析单细胞染色体可访问性测序 (scCAS) 数据的新方法. 咖啡有效捕捉细胞异质性,并有助于从表观基因组数据中发现功能生物学见解.

关键词:
染色质可访问性 染色质可访问性数据预处理数据预处理.显基因组是一个表观基因组.功能选择 功能选择一个单细胞的单细胞.

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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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