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选择性和强大的PROTAC降解c-Src激酶的降解剂

Wuxiang Mao1, Nathalie M Vandecan1, Christopher R Bingham1

  • 1Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109, United States.

ACS chemical biology
|December 19, 2023
PubMed
概括

研究人员开发了新型的蛋白质分解向金马 (PROTACs),可以选择性地降解c-Src,这是一种涉及癌症的蛋白质激酶. 这种向降解为控制癌细胞增殖提供了与传统抑制相比显著的药理优势.

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