丹麦在辅助生殖技术后出生的儿童超重或肥胖:基于人口的队列研究
Kristina Laugesen1, Katalin Veres1, Sonia Hernandez-Diaz2
1Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
PLoS medicine
|December 19, 2023
概括
辅助生殖技术 (ART) 和通过子宫内授精 (OI/IUI) 诱导排卵与儿童肥胖没有关联. 然而,与新鲜胚胎移植相比,冷解胚胎移植与更高的肥胖风险有关.
科学领域:
- 生殖医学 生殖医学
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
背景情况:
- 辅助生殖技术 (ARTs) 与儿童体重指数 (BMI) 之间的联系也在讨论中.
- 以前的研究可能会被父母不孕症因素所混.
研究的目的:
- 调查生育治疗和儿童BMI之间的关联.
- 根据父母不孕症的原因进行调整和分层.
主要方法:
- 丹麦对327,301名儿童的队列研究 (2007-2012).
- 与在ART,OI/IUI和没有生育治疗后出生的孩子进行比较.
- 用反向概率权重对多个共变量进行调整.
主要成果:
- 在5-8岁时,ART或OI/IUI与超重/肥胖之间没有显著的关联.
- 内细胞质精子注射 (ICSI) 和常规体外受精 (IVF) 之间的BMI没有差异.
- 冷解胚胎移植与新鲜胚胎移植相比,肥胖风险增加1.5倍.
结论:
- ART和OI/IUI与儿童BMI没有关联.
- 冷解胚胎移植显示肥胖风险略有增加,但绝对风险仍然很低.
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