巨大的动物细胞表明有机细胞缩放机制在细胞体积的50倍范围
Alexander Nichols Adams1, Bradford Julian Smith2,3, Thomas John Raad1
1Department of Biology, Colorado State University, Fort Collins, CO, United States.
Evolution; international journal of organic evolution
|December 19, 2023
概括
两动物的细胞大小差异很大. 器官体大小与细胞体积成比例,这表明沙兰的前体模型有限,生物合成能力增加以维持功能.
科学领域:
- 细胞生物学 细胞生物学
- 进化生物学 进化生物学
- 比较生理学比较生理学
背景情况:
- 细胞大小的变化在物种之间和生物体内是显著的.
- 器官细胞缩放对于维持细胞功能与增加细胞大小至关重要.
- 两动物在细胞尺寸方面表现出了显著的多样性.
研究的目的:
- 为了研究两类肠细胞中细胞体积与器官细胞含量之间的比例.
- 测试机关细胞缩放遵循跨不同细胞大小的一致规则的假设.
- 探索对细胞功能和进化适应的影响.
主要方法:
- 对3种两动物物种的分析,肠细胞体积在228至10,593μm3.3之间.
- 使用传输电子显微镜检查细胞超结构.
- 量化核,线粒体,内质网膜和戈尔吉装置的尺寸.
主要成果:
- 核体积尺度与半径,而线粒体体积尺度与网络长度.
- 细胞内膜网膜和戈尔吉仪器的缩放显示了中间模式.
- 所有四种主要器官类型的总体体积都以细胞体积的比例增加.
- 器官细胞缩放在细胞大小的50倍范围内是一致的.
结论:
- 两类肠细胞中的有机细胞缩放支持有限的前体模型.
- 细胞缩放似乎遵循保留原则,尽管功能需求各不相同.
- 沙兰可能具有增强的生物合成能力,以支持大细胞体积和维持蛋白质度.
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