患有艾滋病毒的绝经后妇女的骨质,骨折风险和相关因素
Paula R Leite-Silva, Rebeca S Pinheiro1, João M B Barbosa-Ferreira
1Pós-graduação em Imunologia Básica e Aplicada, Universidade Federal doAmazonas, Manaus, Brazil.
Menopause (New York, N.Y.)
|December 19, 2023
概括
亚马逊地区艾滋病毒感染的绝经后妇女有较高的低骨质率. 与艾滋病毒阴性女性相比,她们的骨折风险得分更高,腿部部骨密度更低.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 患有艾滋病毒 (WLH) 的绝经后妇女可能面临独特的骨健康挑战.
- 抗逆转录病毒疗法 (ART) 和艾滋病毒本身可以影响骨矿物质密度.
- 了解亚马逊等不同地区的WLH骨健康至关重要.
研究的目的:
- 为了确定低骨质量 (骨质疏松症/骨质疏松症) 在巴西绝经后WLH的患病率. 在亚马逊.
- 在这个人群中确定与低骨质量相关的因素.
- 为了评估与HIV阴性女性相比,绝经后妇女的骨折风险.
主要方法:
- 一项队列研究,对100名绝经后妇女和100名年龄相匹配的HIV阴性妇女进行横截面评估.
- 用双能X射线吸收计测量腰椎 (LS) 和大腿部 (FN) 的骨矿物质密度.
- 使用10年骨折风险评估工具 (FRAX) 评估骨折风险.
主要成果:
- 在WLH中观察到更早的更年期发作.
- 骨质疏松症/骨质疏松症患病率没有显著差异,但WLH在股骨部的T-score较低.
- 在WLH中,主要骨质疏松和关节骨折的FRAX平均得分更高,尽管两组的整体风险较低.
- 绝经后的岁月,更高的BMI和更高的FRAX得分与WLH有关;身体活动在HIV阴性女性中更高.
- 在WLH中,较低的FN T分数与更年期和BMI相关;LS T分数和FRAX骨折分数与更年期相关.
结论:
- 在亚马逊地区的巴西绝经后妇女中发现了低骨质的高患病率.
- 与艾滋病毒阳性女性相比,艾滋病毒感染女性的骨折风险得分较高,部骨密度较低.
- 进一步的研究和有针对性的干预措施是有必要的,以解决这个脆弱人群的骨健康问题.
更多相关视频
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
10.3K
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:25Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
01:29Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K