埃利斯尔:早期晚期综合合成致死率预测在癌症
Yasin I Tepeli1, Colm Seale1,2, Joana P Gonçalves1
1Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology, Delft, The Netherlands.
Bioinformatics (Oxford, England)
|December 19, 2023
概括
我们开发了ELISL,这是一种用于预测合成致命性 (SL) 基因对的新型计算方法. ELISL克服了数据偏差,改善了抗癌点的识别,显示了个性化癌症治疗的潜力.
科学领域:
- 计算生物学是一种计算生物学.
- 基因组学就是基因组学.
- 癌症研究 癌症研究
背景情况:
- 合成致死性 (SL) 疗法通过利用基因漏洞提供有针对性的抗癌治疗,副作用较少.
- 目前的计算SL预测方法面临挑战,原因是数据选择偏差和癌症特异性OMIC数据的有限可用性.
- 序列相似性作为基因功能和关节本质性的预测因素仍然是一个未得到充分利用的资源.
研究的目的:
- 引入ELISL (早期晚期集成SL预测),这是一个用于预测合成致死性基因对的新型计算框架.
- 解决现有方法的局限性,包括选择偏差和依赖稀缺的组织特异性omics数据.
- 为了利用蛋白质序列嵌入和集成的奥米克数据来进行可靠的SL预测.
主要方法:
- 埃利斯尔采用森林集合,将无语境蛋白质序列嵌入与来自细胞系和组织的特定语境奥米克数据相结合.
- 该方法在八种癌症类型中进行了评估,以评估其稳定性和预测性能.
- 分析包括已知的SL基因的恢复和跨癌症预测能力.
主要成果:
- 与现有方法相比,ELISL在选择偏差方面表现出优越的稳定性.
- 该框架成功地恢复了已知的合成致死性基因对.
- 在跨癌症预测方面,ELISL显示出有前途的表现.
- 在BRCA基因和ELISL预测对 (HH,FGF,WNT,NEIL家族) 中同时发生的突变与患者生存率的改善相关.
结论:
- ELISL提供了一种强大而有效的计算方法,用于识别合成致命性相互作用.
- 该方法克服数据限制并识别新型SL对的能力对抗癌症药物发现具有重大潜力.
- 研究结果表明,针对预测SL对的治疗策略可以改善各种癌症类型患者的治疗结果.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K