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在狗中复发的Escherichia coli细菌性尿症的多中心分子研究
Tessa E LeCuyer1, Rance K Sellon2, Barbara A Byrne3
1Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Washington Animal Disease Diagnostic Laboratory, Washington State University, Pullman, WA, USA.
Veterinary microbiology
|December 19, 2023
概括
大多数狗狗的复发性尿路感染 (UTI) 是由同一种在尿路中持续存在的大肠杆菌菌株引起的. 这表明膀可以作为大肠杆菌的长期储存库,导致反复出现的尿路感染.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 狗的健康 狗的健康
背景情况:
- 大肠杆菌是狗中复发性尿路感染 (UTI) 的主要原因.
- 区分持续感染和再感染至关重要,但在标准诊断方面具有挑战性.
研究的目的:
- 为了测试假设,最常见的狗大肠杆菌菌是来自同一个大肠杆菌菌株的.
- 为了调查大肠杆菌在狗尿道内持续存在的可能性.
主要方法:
- 在美国五个兽医实验室进行了98个尿路大肠杆菌分离的分子类型测定,这些分离物来自5个美国兽医实验室中出现复发性细菌病的狗.
- 对42只多个尿样呈阳性的狗中大肠杆菌菌株复发的分析.
主要成果:
- 一个单一的大肠杆菌菌株在62% (26/42) 的狗中引起了复发性细菌尿,有时长达8个月.
- 在三只狗的亚临床和临床尿路感染发作中检测到相同的大肠杆菌菌株.
- P-fimbrial粘附基因papA和papC与同一菌株复发有关.
结论:
- 狗的尿膀可以作为长期的,E. coli的亚临床储存库.
- 持续的大肠杆菌菌株可以导致狗的亚临床细菌和临床尿路感染.
- 了解应变持久性是治疗狗复发性尿路感染的关键.
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