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在Risperidone治疗后,PPARα-L162V多态和血LDL胆固醇水平增加之间的关联

Sergej Nadalin¹, Lena Zatković², Vjekoslav Peitl³

¹Department of Psychiatry, General Hospital "Dr. Josip Benčević", Slavonski Brod, Croatia; School of Medicine, Catholic University of Croatia, Zagreb, Croatia.

Prostaglandins, leukotrienes, and essential fatty acids

|December 19, 2023

概括

PPARα L162V多态性没有影响整体精神病治疗反应. 然而,它影响了在接受Risperidone或Paliperidone等特定抗精神病药物治疗的患者中LDL胆固醇的增加.

科学领域:

药物遗传学药物遗传学
神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍

背景情况:

过氧体增殖器激活受体α (PPARα) 和抗精神病药物会影响多不和脂肪酸 (PUFA) 稳态.
PPARα遗传变异可能会影响患者对抗精神病药物的反应.

研究的目的:

研究PPARα L162V多态对精神病患者抗精神病治疗反应的影响.
分析PPARα L162V多态性和临床和代谢结果之间的关联,包括阳性和阴性综合征量表 (PANSS) 评分和代谢综合征参数.

主要方法:

在186名精神病患者中使用聚合酶连锁反应对PPARα L162V多态的基因定型.
在基线和8周抗精神病治疗后评估PANSS得分和代谢参数 (脂质,葡萄糖,BMI).
在65名接受Risperidone,Paliperidone或组合治疗的患者中进行亚组分析.

主要成果:

在整个患者组中,PPARα多态性对整体PANSS得分或代谢参数没有显著影响.
在接受Risperidone,Paliperidone或组合治疗的小组中,PPARα L162V异构体与L162L同构体相比,LDL胆固醇的增加显著更大.
这种PPARα多态表现出强大的效果大小,但对LDL胆固醇变化的贡献很小 (∼12.8%).

结论:

PPARα L162V多态性似乎不会影响精神病患者的抗精神病治疗反应或代谢参数.
在接受Risperidone,Paliperidone或其组合治疗的患者中,PPARα L162V多态和增加的LDL胆固醇水平之间存在特定的关联.
这些发现表明PPARα遗传学在预测特定抗精神病治疗期间脂质代谢变化的过程中可能发挥作用.

关键词:

抗精神病剂是一种抗精神病剂.过氧体增殖器激活的受体α.多态性多态性多态性精神错乱是一种精神病.

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