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脑磁共振成像在COVID-19危急后六个月的发现:一项前性队列研究

Henriikka Ollila¹, Janne Pihlajamaa², Juha Martola²

¹Department of Perioperative, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Journal of critical care

|December 19, 2023

概括

长期的大脑MRI扫描揭示了COVID-19幸存者的脑微血流 (CMB),特别是那些在ICU接受治疗的人. 年龄和氧气使用与CMB有关,而不是COVID-19本身.

科学领域:

神经学神经学
放射学放射学是一门学科.
传染性疾病传染性疾病

背景情况:

众所周知,COVID-19会引起急性神经系统症状.
COVID-19的长期神经系统后果尚不清楚.
这项研究调查了COVID-19后持续的大脑变化.

研究的目的:

在COVID-19患者中评估长期的大脑MRI发现.
为了比较不同COVID-19严重程度组的神经结果.
为了确定与COVID-19后的神经成像异常相关的因素.

主要方法:

潜在的队列研究包括ICU治疗,病房治疗和在家隔离的COVID-19患者,以及非COVID对照.
大脑MRI扫描是在急性COVID-19后六个月进行的.
血神经丝光链 (NfL) 水平作为神经轴损伤的生物标志物测量.

主要成果:

在5.8%的ICU治疗患者中观察到缺血性心脏病发作.
大脑微出血 (CMB) 在ICU治疗患者 (39.1%) 与病房治疗患者 (28.3%),家庭隔离患者 (17.4%) 和对照患者 (22.6%) 相比更为普遍.
年龄较大,血NfL较高,补充氧气日数较多与CMB相关.

结论:

补充氧气使用的年龄和持续时间是CMB的独立预测因素.
COVID-19感染本身与CMBs没有直接关联.
在ICU患者中,CMB的更高患病率可能是由于风险因素的累积.

关键词:

大脑MRI 脑部MRI 脑部在 COVID-19 疫情中,重症监护室的重症监护室是重症监护室的重症监护室.长期的长期的长期的

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