在成年人中,自身免疫性疾病与慢性鼻炎的关联
Sairisheel Gabbi Reddy1, Zayd Al-Asadi2, Ruifeng Cui1
1Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, United States of America.
American journal of otolaryngology
|December 19, 2023
概括
自免疫性疾病与鼻炎的更高风险有关,包括慢性 (CRS) 和复发性急性形式. 这种关联甚至在考虑到患者的其他潜在风险因素时也是如此.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 新兴研究表明,自身免疫性疾病与鼻炎风险增加之间存在潜在联系.
- 用于自身免疫性疾病的免疫调节药物也可能影响鼻炎的发展.
研究的目的:
- 调查自身免疫性疾病与鼻炎发病率之间的关联.
- 为了区分慢性鼻炎 (CRS) 和复发性急性鼻炎 (RARS) 的风险.
主要方法:
- 进行了一项病例控制研究,包括527名鼻炎患者和564名对照患者.
- 患者被诊断为CRS (带或没有鼻) 或RARS.
- 分析了患者特征,并发症和自身免疫性疾病治疗的数据.
主要成果:
- 鼻炎患者更可能患有自身免疫性疾病 (16.5% vs 9.4%) 和初级抗体缺乏 (5.1% vs 0.5%).
- 多变量分析证实了自身免疫性疾病和鼻炎 (OR=1.6) 之间存在显著的关联.
- 在CRS和RARS亚型之间没有发现自身免疫疾病患病率的显著差异.
结论:
- 自身免疫性疾病代表了发展鼻炎的独立风险因素.
- 这些发现支持自身免疫性疾病和慢性和复发性急性鼻炎之间的联系.
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